Immunoglobulin E-Mediated Autoimmunity

Immunoglobulin E-Mediated Autoimmunity

A Novel Immunoglobulin-Immunoglobulin Interaction in Autoimmunity

Well over six decades since its first description, the Rheumatoid Factor (RF)-autoantibodies recognizing Fc (constant) portion of IgG through their own Fab (antigen binding variable segments)-is believed to have come of age. Autoimmune pancreatitis is a unique form of pancreatitis, biologically characterized by an elevated serum IgG4 concentration. Given the fact that IgG4 myeloma proteins can ...

Immunoglobulin E-mediated severe anaphylaxis to paclitaxel.

Immediate hypersensitivity reactions to taxanes have been related to nonspecifi c mediator release from mast cells. While the excipient macrogolglycerol ricinoleate has been implicated in complement or mast cell activation, an immunoglobulin (Ig) E-mediated mechanism has never been demonstrated. We report the case of a 49-year-old woman with a history of isocyanate-induced occupational asthma w...

Immunoglobulin E-Mediated Anaphylaxis to Sesame

To the Editor: The incidence of food allergy is age dependent, particularly affecting children and young patients. When selfreported, it ranges between 3% and 35%. However, placebocontrolled food challenge is positive in just 1% to 4% of all suspected cases. In elderly, anaphylactic reactions tend to be less severe, and a primary manifestation at this age is unusual. A 70-year-old white man nee...

Cell Therapy for Prophylactic Tolerance in Immunoglobulin E-mediated Allergy

BACKGROUND Therapeutic strategies for the prophylaxis of IgE-mediated allergy remain an unmet medical need. Cell therapy is an emerging approach with high potential for preventing and treating immunological diseases. We aimed to develop a cell-based therapy inducing permanent allergen-specific immunological tolerance for preventing IgE-mediated allergy. METHODS Wild-type mice were treated wit...